Glomerular Disease

Glomerular Diseases

Glomerulus Collage by JonnySax @

Podocyte Review

  1. Jefferson, J. Ashley, Charles E. Alpers, and Stuart J. Shankland. “Podocyte biology for the bedside.” American Journal of Kidney Diseases 58.5 (2011): 835-845. Download

Membranous Nephropathy

  1. Meryl Waldman and Howard A Austin Treatment of Idiopathic Membranous Nephropathy. JASN September 28, 2012 vol. 23 no. 10 1617-1630 Download
  2.  Zhihong Liu et al Anti-Phospholipase A2 Receptor Antibody in Membranous Nephropathy. JASN June 1, 2011 vol. 22 no. 6 1137-1143.  Download
  3.  Beck Jr LH, Bonegio RG, Lambeau G, et al: M-type phospholipase A2 receptor as target antigen in idiopathic membranous nephropathy. N Engl J Med 2009; 361:11-21 Download
  4. Polanco et al. Spontaneous Remission of Nephrotic Syndrome in Idiopathic Membranous Nephropathy. JASN April 1, 2010 vol. 21 no. 4 697-704 Download
  5.  Ponticelli et al. Methylprednisolone plus Chlorambucil as Compared with Methylprednisolone Alone for the Treatment of Idiopathic Membranous Nephropathy. N Engl J Med 1992; 327:599-603. Download
  6.  Ponticelli C, Altieri P, Scolari F, et al: A randomized study comparing methylprednisolone plus chlorambucil versus methylprednisolone plus cyclophosphamide in idiopathic membranous nephropathy. J Am Soc Nephrol 1998; 9:444-450. Download
  7. Jha V, Ganguli A, Saha TK, et al: A randomized, controlled trial of steroids and cyclophosphamide in adults with nephrotic syndrome caused by idiopathic membranous nephropathy. J Am Soc Nephrol 2007; 18:1899-1904. Download
  8. Praga M et al. Tacrolimus monotherapy in membranous nephropathy: A  randomized controlled trial. Kidney International (2007) 71, 924–930. doi:10.1038/; published online 21 March 2007.
  9. Bomback AS,Radhakrishnan J. Treatment of nephrotic syndrome with adrenocorticotropic hormone (ACTH). Discov Med 12: 91–96, 2011 Read Online
  10. Gong, Rujun. “The renaissance of corticotropin therapy in proteinuric nephropathies.” Nature Reviews Nephrology 8.2 (2011): 122-128. Download

Lupus Nephritis

  1.  ALMS Trial – Induction with MMF: Appel, Gerald B., et al. “Mycophenolate mofetil versus cyclophosphamide for induction treatment of lupus nephritis.” Journal of the American Society of Nephrology 20.5 (2009): 1103-1112.Download
  2. ALMS Trial – Maintenance with MMF: Dooley, Mary Anne, et al. “Mycophenolate versus azathioprine as maintenance therapy for lupus nephritis.” New England Journal of Medicine 365.20 (2011): 1886-1895. ( MMF had better outcomes as compared to Azathioprine, sponsored by Aspreva) Download
  3. LUNAR Trial: Rovin, B. H., et al. “for the LUNAR Investigator Group: Efficacy and safety of rituximab in patients with active proliferative lupus nephritis: The lupus nephritis assessment with rituximab (LUNAR) study.” Arthritis Rheum 64.4 (2012): 1215-1226.Download
  4. MAINTAIN Nephritis Trial: Houssiau, Frédéric A., et al. “Azathioprine versus mycophenolate mofetil for long-term immunosuppression in lupus nephritis: results from the MAINTAIN Nephritis Trial.” Annals of the rheumatic diseases 69.12 (2010): 2083-2089. (Smaller trial that showed no difference between MMF and AZA in maintence of LN) Download


  1. Wei, Changli, et al. “Circulating urokinase receptor as a cause of focal segmental glomerulosclerosis.” Nature medicine 17.8 (2011): 952-960. Download

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