Nephrology Practice Board Questions – FSGS

As I’ve been studying I’ve been trying to make up questions of information that I found to be important or interesting (at least to me). These questions and those to follow are a random grouping of  multiple choice, true/false, or guess what I’m thinking.

1.) Collapsing FSGS is associated with what disease/drugs?

2.) Which monosaccharide sugar has been shown to normalize the permeability factor in FSGS?

A. Fructose
B. Sucrose
C. Galactose
D. Glucose

3.) Secondary forms of FSGS occur via what mechanism?

4.) In children with FSGS as the cause of ESRD a transplant from a living related donor gave a better allograft survival than from a cadaveric donor. True or False?

5.) Mutations to APOL1 are protective against what infectious parasite?

A. Plasmodium falciparum
B. Trypanosoma brucei
C. Giardia lamdia
D. Toxoplasma gondii

6.) Pseudocrescents (hyperplastic visceral epithelial cells swollen and crowded together) are associated with which variant of FSGS?
A. Collpasing
B. Perihilar
C. Tip
D. Cellular

7.) Secondary forms of FSGS associated with hyperfiltration such as remnant kidney and obesity-related glomerulopathy typically have lower levels of proteinuria. True/False?

8.) The structure in the picture is associated with which diseases?

 

 

 

 

 

 

 

 

9.) What IF pattern is often seen in FSGS?
A. IgM
B. IgA
C. C3
D. C4d
E. A and C
F. A and B
G. B and D

10.) What is the first-line treatment of FSGS in patients with nephrotic syndrome?
A. Pulse methylprednisolone for 3 days
B. Prednisone 1mg/kg/day for 6-8 weeks with subsequent tapering
C. Cyclophosphamide 0.5mg/m2/day IV for 3 months
D. No immunosuppression just conservative therapy

11.) What medications/drugs are associated with secondary FSGS?

12.) What risk factors are best prognosticators for progression to ESRD in FSGS at biopsy?
A. Reduced GFR
B. Greater degree of proteinuria
C. Greater degree of intersitial fibrosis.
D. All of the above

Answers
-Adrian



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